| Identification |
|---|
| HMDB Protein ID
| HMDBP13591 |
| Secondary Accession Numbers
| None |
| Name
| Carnosine N-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| CARNMT1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carnosine metabolic process |
| methylation |
| Cellular Component |
| cytosol |
| nucleus |
| Molecular Function |
| S-adenosylmethionine-dependent methyltransferase activity |
| protein homodimerization activity |
| carnosine N-methyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 449 |
| Molecular Weight
| 52076.38 |
| Theoretical pI
| 5.512 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| F1N9S8 |
| UniProtKB/Swiss-Prot Entry Name
| CARME_CHICK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Authors unspecified: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature. 2004 Dec 9;432(7018):695-716. doi: 10.1038/nature03154. [PubMed:15592404 ]
- Drozak J, Piecuch M, Poleszak O, Kozlowski P, Chrobok L, Baelde HJ, de Heer E: UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase. J Biol Chem. 2015 Jul 10;290(28):17190-205. doi: 10.1074/jbc.M115.640037. Epub 2015 May 22. [PubMed:26001783 ]
|
