| Identification |
|---|
| HMDB Protein ID
| HMDBP12698 |
| Secondary Accession Numbers
| None |
| Name
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
| Synonyms
|
- 24-OHase
- Vitamin D(3) 24-hydroxylase
- Cytochrome P450 24A1
- Cytochrome P450-CC24
|
| Gene Name
| CYP24A1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin. |
| Pathways
|
- MicroRNAs in cancer
- Parathyroid hormone synthesis, secretion and action
- Steroid biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| fatty acid omega-oxidation |
| vitamin D metabolic process |
| osteoblast differentiation |
| vitamin D catabolic process |
| response to vitamin D |
| Cellular Component |
| mitochondrion |
| nucleoplasm |
| Molecular Function |
| vitamin D 24-hydroxylase activity |
| 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity |
| 25-hydroxycholecalciferol-23-hydroxylase activity |
| vitamin D 25-hydroxylase activity |
| iron ion binding |
| 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity |
| 25-hydroxycholecalciferol-24-hydroxylase activity |
| heme binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 514 |
| Molecular Weight
| 59452.655 |
| Theoretical pI
| 9.031 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q64441 |
| UniProtKB/Swiss-Prot Entry Name
| CP24A_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y: Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003 Dec;17(12):2393-403. Epub 2003 Oct 3. [PubMed:14528024 ]
- Akeno N, Saikatsu S, Kawane T, Horiuchi N: Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3. Endocrinology. 1997 Jun;138(6):2233-40. [PubMed:9165006 ]
- Itoh S, Yoshimura T, Iemura O, Yamada E, Tsujikawa K, Kohama Y, Mimura T: Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3. Biochim Biophys Acta. 1995 Oct 17;1264(1):26-8. doi: 10.1016/0167-4781(95)00147-9. [PubMed:7578252 ]
|
