| Identification |
|---|
| HMDB Protein ID
| HMDBP11803 |
| Secondary Accession Numbers
| None |
| Name
| Lysine-specific demethylase 8 |
| Synonyms
|
- JmjC domain-containing protein 5
- Jumonji domain-containing protein 5
|
| Gene Name
| KDM8 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
|
| Pathways
|
Not Available
|
| Reactions
|
| Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen → protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2) |
details
|
| Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen → protein L-lysine + Succinic acid + Formaldehyde + CO(2) |
details
|
|
| GO Classification
|
| Biological Process |
| G2/M transition of mitotic cell cycle |
| positive regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| Cellular Component |
| nucleus |
| Molecular Function |
| metal ion binding |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| chromatin binding |
| histone demethylase activity (H3-K36 specific) |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p12.1 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 50851.565 |
| Theoretical pI
| 5.702 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|223942018|ref|NP_001138820.1| lysine-specific demethylase 8 isoform 1 [Homo sapiens]
MSREKCSPGEGAEEGRGSEASGLKASAGHGTEPAGGGPMAGDTHCPAEPLAREGTLWEAL
RALLPHSKED
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8N371 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:25840 |
| References |
|---|
| General References
| Not Available |
