Hmdb loader
Identification
HMDB Protein ID HMDBP09327
Secondary Accession Numbers
  • 15164
Name E3 ubiquitin-protein ligase MARCH9
Synonyms
  1. MARCH-IX
  2. Membrane-associated RING finger protein 9
  3. Membrane-associated RING-CH protein IX
  4. RING finger protein 179
Gene Name MARCH9
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location
  1. Golgi apparatus membrane
  2. Lysosome membrane
  3. Multi-pass membrane protein
  4. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 12q14.1
SNPs MARCH9
Gene Sequence
>1041 bp
ATGCTCAAGTCTCGGCTCCGCATGTTTCTGAACGAGCTGAAGCTGCTGGTGCTGACAGGC
GGGGGGCGGCCCCGGGCCGAGCCGCAACCCCGGGGGGGCCGGGGAGGCGGCTGCGGCTGG
GCGCCCTTCGCTGGTTGCTCCACCCGGGACGGCGACGGCGACGAGGAGGAGTACTACGGG
TCGGAGCCGCGGGCCCGGGGCCTGGCCGGCGACAAGGAGCCGCGGGCCGGACCCCTGCCG
CCGCCCGCGCCGCCGCTGCCGCCCCCGGGCGCGCTGGACGCCCTGTCGCTCAGCAGTAGC
CTGGACAGCGGACTCCGAACCCCTCAGTGCCGGATCTGCTTCCAGGGCCCGGAGCAGGGG
GAGCTCTTAAGCCCCTGCCGCTGCGACGGCTCAGTGCGCTGCACGCATCAGCCCTGCCTC
ATCCGCTGGATCAGCGAGAGGGGCTCCTGGAGCTGTGAGCTCTGCTACTTCAAGTACCAG
GTCCTGGCGATCAGCACCAAGAACCCACTGCAGTGGCAGGCCATCTCCCTGACGGTCATC
GAGAAGGTCCAGATTGCTGCCATAGTTCTGGGCTCGCTCTTCCTGGTTGCCAGCATCTCC
TGGCTCATCTGGTCCTCACTCAGCCCTTCAGCCAAGTGGCAACGACAGGATCTGCTCTTT
CAGATCTGCTACGGCATGTATGGCTTCATGGATGTCGTCTGCATAGGCCTCATCATCCAT
GAAGGCTCCTCTGTCTACCGCATCTTCAAGCGCTGGCAGGCAGTGAACCAGCAGTGGAAG
GTCCTAAATTATGACAAGACCAAGGACATAGGAGGAGATGCAGGGGGAGGGACGGCAGGG
AAGTCAGGCCCCAGGAACTCACGGACGGGCCCCACCTCTGGGGCCACGAGCCGCCCCCCA
GCTGCCCAGCGCATGCGGACGCTCTTGCCTCAGCGCTGCGGTTATACAATCTTGCACCTC
CTTGGGCAGCTGCGGCCACCAGATGCCCGTTCCAGCTCCCATTCTGGCCGAGAGGTTGTC
ATGAGGGTCACTACAGTCTGA
Protein Properties
Number of Residues 346
Molecular Weight 37772.1
Theoretical pI 9.35
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 185-205
  • 219-239
Protein Sequence
>E3 ubiquitin-protein ligase MARCH9
MLKSRLRMFLNELKLLVLTGGGRPRAEPQPRGGRGGGCGWAPFAGCSTRDGDGDEEEYYG
SEPRARGLAGDKEPRAGPLPPPAPPLPPPGALDALSLSSSLDSGLRTPQCRICFQGPEQG
ELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNPLQWQAISLTVI
EKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIH
EGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNSRTGPTSGATSRPP
AAQRMRTLLPQRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTTV
GenBank ID Protein 40255016
UniProtKB/Swiss-Prot ID Q86YJ5
UniProtKB/Swiss-Prot Entry Name MARH9_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_138396.4
GeneCard ID MARCH9
GenAtlas ID MARCH9
HGNC ID HGNC:25139
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Hoer S, Smith L, Lehner PJ: MARCH-IX mediates ubiquitination and downregulation of ICAM-1. FEBS Lett. 2007 Jan 9;581(1):45-51. Epub 2006 Dec 8. [PubMed:17174307 ]
  4. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K: Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004 Feb;78(3):1109-20. [PubMed:14722266 ]