Showing Protein E3 ubiquitin-protein ligase MARCH8 (HMDBP09269)

• 15097

1. Cellular modulator of immune recognition
2. MARCH-VIII
3. Membrane-associated RING finger protein 8
4. Membrane-associated RING-CH protein VIII
5. RING finger protein 178
6. c-MIR

1. Lysosome membrane
2. Multi-pass membrane protein
3. Multi-pass membrane protein
4. Multi-pass membrane protein
5. Cytoplasmic vesicle membrane
6. Early endosome membrane

>876 bp
ATGAGCATGCCACTGCATCAGATCTCTGCCATTCCATCCCAGGATGCCATCTCTGCTAGA
GTCTACAGAAGTAAGACCAAAGAAAAGGAGAGGGAAGAACAGAATGAGAAGACTTTGGGA
CATTTCATGAGTCATTCAAGCAACATTTCTAAGGCTGGGAGTCCTCCGTCAGCATCAGCT
CCGGCTCCGGTGTCCTCCTTCTCTCGCACTTCTATCACGCCATCCAGCCAGGACATCTGC
AGGATCTGCCACTGTGAAGGAGATGATGAGAGCCCCCTGATCACCCCCTGCCACTGCACA
GGAAGCCTCCACTTCGTGCACCAGGCCTGCCTGCAGCAGTGGATCAAGAGCTCCGACACG
CGCTGCTGCGAGCTCTGCAAGTATGAGTTCATCATGGAGACCAAGCTGAAGCCACTGAGA
AAATGGGAGAAGTTGCAGATGACGTCCAGCGAGCGCAGGAAGATCATGTGCTCAGTGACA
TTCCACGTCATTGCCATCACATGTGTGGTCTGGTCCTTGTATGTGCTCATTGACCGTACT
GCTGAGGAGATCAAGCAGGGGCAGGCAACAGGAATCCTAGAATGGCCCTTTTGGACTAAA
TTGGTGGTTGTGGCCATCGGCTTCACCGGAGGACTTCTTTTTATGTATGTTCAGTGTAAA
GTGTATGTGCAATTGTGGAAGAGACTCAAGGCCTATAATAGAGTGATCTATGTTCAAAAC
TGTCCAGAAACAAGCAAAAAGAATATTTTTGAAAAATCTCCACTAACAGAGCCCAACTTT
GAAAATAAACATGGATATGGAATCTGTCATTCCGACACAAACTCTTCTTGTTGCACAGAG
CCTGAAGACACTGGAGCAGAAATCATTCACGTCTGA

• zf-C3HC4 (PF00097 )

• None

• 157-177
• 197-217

>E3 ubiquitin-protein ligase MARCH8
MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA
PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT
RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT
AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN
CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV

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4. Goto E, Ishido S, Sato Y, Ohgimoto S, Ohgimoto K, Nagano-Fujii M, Hotta H: c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem. 2003 Apr 25;278(17):14657-68. Epub 2003 Feb 11. [PubMed:12582153 ]
5. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K: Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004 Feb;78(3):1109-20. [PubMed:14722266 ]
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7. Lapaque N, Jahnke M, Trowsdale J, Kelly AP: The HLA-DRalpha chain is modified by polyubiquitination. J Biol Chem. 2009 Mar 13;284(11):7007-16. doi: 10.1074/jbc.M805736200. Epub 2008 Dec 31. [PubMed:19117940 ]
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