Human Metabolome Database: Showing Protein D-glucuronyl C5-epimerase (HMDBP09167)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP09167

Secondary Accession Numbers

14923

Name

D-glucuronyl C5-epimerase

Synonyms

Heparin/heparan sulfate:glucuronic acid C5-epimerase

Gene Name

GLCE

Protein Type

Enzyme

Biological Properties

General Function

Involved in racemase and epimerase activity, acting on carbohydrates and derivatives

Specific Function

Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acids

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
racemase and epimerase activity
racemase and epimerase activity, acting on carbohydrates and derivatives
isomerase activity
Process
polysaccharide metabolic process
metabolic process
primary metabolic process
carbohydrate metabolic process
polysaccharide biosynthetic process
aminoglycan biosynthetic process
glycosaminoglycan biosynthetic process

Cellular Location

Golgi apparatus membrane
Single-pass type II membrane protein

Gene Properties

Chromosome Location

Chromosome:1

Locus

15q23

SNPs

GLCE

Gene Sequence

>1854 bp
ATGCGTTGCTTGGCAGCTCGGGTCAACTATAAGACTTTGATTATTATCTGCGCACTCTTC
ACTTTGGTCACAGTACTTTTGTGGAATAAGTGTTCCAGTGACAAAGCAATCCAGTTTCCA
CGGCGTTCGAGTAGTGGCTTCAGAGTGGATGGGTTTGAAAAAAGAGCAGCAGCATCTGAG
AGTAACAACTATATGAACCACGTGGCCAAACAACAGTCTGAGGAAGCATTCCCTCAGGAA
CAGCAGAAAGCACCCCCTGTTGTTGGGGGCTTCAATAGCAATGTGGGAAGTAAGGTGTTA
GGGCTCAAATATGAAGAAATTGACTGTCTCATAAATGATGAACACACAATTAAAGGGAGA
CGAGAGGGGAACGAAGTCTTTCTTCCATTCACTTGGGTTGAGAAATATTTTGATGTTTAT
GGAAAGGTGGTTCAGTATGATGGCTATGATCGGTTTGAATTCTCTCATAGCTATTCCAAA
GTCTATGCACAGAGAGCCCCCTATCACCCCGATGGTGTGTTTATGTCTTTTGAAGGCTAC
AATGTGGAAGTCCGAGACAGAGTCAAGTGCATAAGTGGGGTTGAAGGTGTGCCATTATCT
ACACAATGGGGACCTCAAGGCTATTTCTATCCAATCCAGATTGCACAGTATGGATTAAGT
CATTACAGCAAGAATCTAACTGAGAAACCTCCTCACATAGAGGTATATGAAACAGCAGAA
GACAGAGACAAAAACAAGCCTAATGACTGGACTGTGCCAAAGGGCTGCTTTATGGCGAAT
GTGGCTGATAAGTCTAGATTCACCAATGTCAAACAGTTTATTGCACCAGAAACCAGTGAA
GGTGTATCCTTGCAACTGGGAAACACAAAAGATTTTATTATTTCATTTGACCTCAAGTTC
TTGACAAATGGAAGTGTGTCCGTGGTTCTAGAGACCACAGAAAAGAATCAGCTCTTCACT
ATACATTATGTCTCAAATGCTCAGCTAATTGCTTTTAAAGAAAGAGATATATACTATGGC
ATTGGGCCCAGAACTTCATGGAGCACAGTTACCAGGGACCTGGTCACTGACCTCAGGAAA
GGAGTGGGTCTTTCAAACACAAAAGCTGTCAAGCCAACCAAAATAATGCCCAAGAAGGTG
GTTAGGTTGATTGCAAAAGGTAAGGGATTCCTCGACAACATTACCATCTCTACCACAGCC
CACATGGCTGCATTTTTTGCTGCTAGTGATTGGCTAGTAAGGAACCAGGATGAGAAAGGT
GGCTGGCCAATTATGGTGACCCGTAAGTTAGGGGAAGGGTTCAAGTCTTTAGAGCCAGGA
TGGTATTCTGCCATGGCCCAAGGGCAAGCCATTTCTACATTAGTCAGGGCCTATCTGTTA
ACAAAAGACCATATATTCCTCAATTCAGCTTTAAGGGCAACAGCCCCTTATAAGTTTCTA
TCTGAGCAGCATGGAGTTAAAGCTGTGTTTATGAATAAACATGACTGGTATGAAGAATAT
CCAACCACACCTAGCTCTTTTGTTTTAAATGGCTTTATGTATTCTTTAATTGGGCTGTAT
GACTTAAAAGAAACTGCAGGGGAAAAACTCGGAAAAGAAGCAAGGTCCTTGTATGAGCGT
GGCATGGAATCTCTTAAAGCCATGCTGCCCTTGTATGACACTGGCTCAGGAACCATCTAT
GACCTCCGTCACTTCATGCTTGGCATCGCTCCTAACCTGGCTCGCTGGGACTATCATACC
ACCCACATCAATCAGTTGCAGCTACTCAGTACCATTGATGAGTCCCCAGTCTTCAAAGAA
TTTGTCAAGAGGTGGAAAAGCTACCTTAAAGGCAGCAGGGCAAAGCACAACTAG

Protein Properties

Number of Residues

617

Molecular Weight

70100.5

Theoretical pI

9.32

Pfam Domain Function

C5-epim_C (PF06662 )

Signals

None

Transmembrane Regions

12-28

Protein Sequence

>D-glucuronyl C5-epimerase
MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSSSGFRVDGFEKRAAASE
SNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGLKYEEIDCLINDEHTIKGR
REGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRAPYHPDGVFMSFEGY
NVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAE
DRDKNKPNDWTVPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKF
LTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTVTRDLVTDLRK
GVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTAHMAAFFAASDWLVRNQDEKG
GWPIMVTRKLGEGFKSLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFL
SEQHGVKAVFMNKHDWYEEYPTTPSSFVLNGFMYSLIGLYDLKETAGEKLGKEARSLYER
GMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPVFKE
FVKRWKSYLKGSRAKHN

External Links

GenBank ID Protein

51317380

UniProtKB/Swiss-Prot ID

O94923

UniProtKB/Swiss-Prot Entry Name

GLCE_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [PubMed:16572171 ]
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Dec 31;5(6):355-64. [PubMed:10048485 ]