Showing Protein Protein phosphatase Slingshot homolog 1 (HMDBP08956)

• 14685

1. SSH-1L
2. SSH-like protein 1
3. hSSH-1L

• Regulation of actin cytoskeleton

1. Cytoplasm
2. cytoskeleton
3. Cell projection
4. Cleavage furrow
5. lamellipodium
6. Midbody

>3150 bp
ATGGCCCTGGTGACCCTGCAGCGCTCGCCCACGCCCAGCGCCGCCTCCTCCTCGGCCAGC
AACAGCGAGTTGGAGGCTGGCAGCGAAGAAGATCGAAAATTAAACCTCAGCTTAAGTGAG
AGCTTTTTCATGGTGAAAGGCGCAGCCCTCTTCTTACAACAGGGAAGCAGCCCTCAAGGC
CAGCGGAGTCTTCAGCACCCCCACAAGCATGCAGGTGATCTGCCTCAACATCTTCAGGTG
ATGATCAACCTTCTGCGTTGCGAAGACAGAATCAAGCTGGCAGTGCGCCTGGAGAGCGCC
TGGGCGGACCGGGTCCGGTACATGGTGGTGGTGTACAGCAGCGGGCGCCAGGACACCGAG
GAGAATATCTTGCTGGGAGTGGACTTTTCCAGTAAGGAAAGTAAAAGCTGCACCATTGGG
ATGGTTCTCCGACTGTGGAGCGACACGAAAATCCACCTTGATGGAGATGGTGGGTTCAGC
GTGAGCACAGCAGGAAGGATGCACATATTTAAGCCTGTGTCTGTCCAGGCCATGTGGTCT
GCCCTGCAGGTGCTTCACAAGGCCTGCGAAGTGGCCCGGAGGCACAACTACTTCCCCGGG
GGTGTAGCTCTCATCTGGGCTACCTACTATGAGAGCTGCATCAGCTCCGAGCAGAGCTGC
ATCAACGAGTGGAACGCCATGCAGGACCTGGAGTCTACGCGGCCCGACTCCCCCGCGCTA
TTTGTGGACAAGCCCACTGAAGGGGAAAGGACCGAGCGCCTCATCAAAGCCAAGCTCCGA
AGCATCATGATGAGCCAGGATCTAGAAAATGTGACTTCCAAAGAGATTCGTAATGAATTA
GAGAAACAGATGAATTGTAACTTGAAGGAACTCAAGGAATTTATAGACAATGAGATGCTA
CTTATCTTGGGACAGATGGACAAGCCCTCCCTTATCTTCGATCATCTTTATCTCGGCTCT
GAATGGAATGCATCCAATCTGGAGGAACTGCAGGGCTCAGGGGTTGATTACATTTTAAAT
GTTACCAGAGAAATCGATAATTTTTTTCCTGGCTTATTTGCATATCATAACATCCGAGTC
TACGATGAAGAGACCACAGACCTCCTCGCCCACTGGAATGAAGCGTATCATTTTATAAAC
AAAGCGAAGAGGAACCATTCCAAGTGCCTGGTGCATTGCAAAATGGGCGTGAGTCGCTCG
GCCTCCACAGTCATAGCCTATGCAATGAAGGAATTCGGCTGGCCTCTGGAAAAAGCATAT
AACTATGTAAAGCAGAAGCGCAGCATCACGCGCCCCAACGCGGGCTTTATGAGGCAGCTG
TCTGAGTATGAAGGCATCTTGGATGCAAGCAAACAGCGGCACAACAAGCTGTGGCGTCAG
CAGACAGACAGCAGCCTCCAGCAGCCTGTGGATGACCCTGCAGGACCTGGCGACTTCTTG
CCAGAGACCCCAGATGGCACCCCGGAAAGCCAGCTGCCCTTCTTGGATGATGCCGCCCAG
CCCGGCTTAGGGCCCCCCCTCCCCTGCTGTTTCCGGCGACTCTCAGACCCCCTTCTGCCT
TCCCCTGAGGATGAAACTGGCAGCTTGGTCCACCTGGAGGATCCGGAGAGGGAGGCTCTG
TTGGAGGAAGCTGCTCCACCTGCAGAGGTGCACAGGCCGGCCAGACAGCCCCAGCAAGGT
TCCGGACTCTGTGAGAAGGATGTGAAGAAGAAACTAGAGTTTGGGAGTCCCAAAGGTCGG
AGCGGCTCCTTGCTGCAGGTGGAGGAGACGGAAAGGGAGGAGGGCCTGGGAGCAGGGAGG
TGGGGGCAGCTTCCAACCCAGCTCGATCAAAACCTGCTCAACTCGGAGAACCTAAACAAC
AACAGCAAGAGGAGCTGTCCCAACGGCATGGAGGATGATGCTATATTTGGGATCCTTAAC
AAAGTGAAGCCTTCCTATAAATCCTGTGCCGACTGCATGTACCCTACAGCCAGCGGGGCT
CCTGAGGCCTCCAGGGAGCGATGTGAGGACCCCAATGCTCCCGCCATCTGCACCCAGCCA
GCCTTCCTACCCCACATCACGTCCTCCCCTGTGGCCCACTTGGCCAGCAGGTCCCGTGTT
CCGGAGAAGCCAGCCTCTGGCCCAACCGAACCTCCCCCGTTCCTACCACCAGCAGGCTCC
AGGAGGGCAGACACCAGTGGCCCTGGGGCTGGAGCTGCCCTAGAGCCACCAGCCAGCCTT
TTGGAACCTTCCAGAGAGACCCCAAAAGTCCTGCCAAAGTCCCTCCTTTTGAAGAATTCT
CACTGTGATAAGAACCCTCCCAGCACAGAAGTGGTAATAAAGGAAGAATCGTCACCCAAG
AAAGATATGAAGCCAGCCAAGGACCTGAGGCTTCTGTTCAGTAATGAATCTGAGAAGCCG
ACAACCAACAGCTACCTGATGCAGCACCAGGAGTCCATCATTCAGCTGCAGAAGGCAGGC
TTGGTCCGCAAGCACACCAAAGAGCTAGAGCGGCTGAAGAGCGTGCCTGCAGACCCAGCA
CCTCCCTCCAGGGATGGCCCTGCCAGCAGGCTGGAGGCCAGCATCCCCGAGGAGAGCCAG
GATCCAGCCGCGCTCCACGAGCTGGGCCCCCTGGTTATGCCCAGCCAGGCCGGGAGTGAT
GAGAAGTCAGAGGCCGCCCCCGCTTCATTGGAAGGAGGCTCACTGAAGAGCCCCCCTCCT
TTCTTCTACCGCCTGGACCACACCAGTAGTTTCTCAAAAGACTTTCTGAAGACCATCTGC
TACACCCCCACCTCCTCTTCCATGAGCTCCAACCTGACCCGGAGCTCCAGCAGCGATAGC
ATCCACAGTGTCCGTGGGAAGCCCGGGCTGGTGAAGCAGCGGACACAGGAGATTGAGACC
CGGCTCCGGCTGGCGGGCCTCACCGTCTCTTCCCCACTGAAGCGCTCACACTCTCTTGCC
AAGCTGGGGAGTCTCACCTTCTCAACGGAAGACCTGTCCAGTGAGGCTGACCCGTCCACC
GTCGCTGACTCCCAGGACACCACTTTGAGTGAATCTTCCTTCTTGCATGAGCCCCAGGGA
ACCCCGAGGGACCCAGCTGCAACCTCCAAACCATCAGGGAAACCCGCCCCAGAAAACTTA
AAGAGCCCTTCGTGGATGAGCAAAAGCTGA

• DSPc (PF00782 )
• DEK_C (PF08766 )

>Protein phosphatase Slingshot homolog 1
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQG
QRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTE
ENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPAL
FVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEML
LILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAY
NYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFL
PETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGR
WGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGA
PEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGS
RRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPK
KDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPA
PPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPP
FFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIET
RLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQG
TPRDPAATSKPSGKPAPENLKSPSWMSKS

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4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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9. Nishita M, Tomizawa C, Yamamoto M, Horita Y, Ohashi K, Mizuno K: Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol. 2005 Oct 24;171(2):349-59. Epub 2005 Oct 17. [PubMed:16230460 ]
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