| Identification |
|---|
| HMDB Protein ID
| HMDBP05360 |
| Secondary Accession Numbers
| |
| Name
| Probable proline dehydrogenase 2 |
| Synonyms
|
- HsPOX1
- Kidney and liver proline oxidase 1
- Probable proline oxidase 2
|
| Gene Name
| PRODH2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in proline dehydrogenase activity |
| Specific Function
| Converts proline to delta-1-pyrroline-5-carboxylate (Probable).
|
| Pathways
|
- Arginine and proline metabolism
- L-proline degradation into L-glutamate
|
| Reactions
|
| Proline + acceptor → 1-Pyrroline-5-carboxylic acid + reduced acceptor |
details
|
|
| GO Classification
|
| Biological Process |
| glutamate biosynthetic process |
| proline catabolic process to glutamate |
| Cellular Component |
| mitochondrial inner membrane |
| Function |
| proline dehydrogenase activity |
| catalytic activity |
| oxidoreductase activity, acting on the ch-nh group of donors |
| oxidoreductase activity |
| Molecular Function |
| proline dehydrogenase activity |
| Process |
| proline catabolic process |
| glutamate metabolic process |
| glutamate biosynthetic process |
| metabolic process |
| cellular metabolic process |
| glutamine family amino acid metabolic process |
| proline metabolic process |
| oxidation reduction |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.1 |
| SNPs
| PRODH2 |
| Gene Sequence
|
>1611 bp
ATGTCGCCCAGGGTAGTCTCAAACTCCTCGGTCTTGGCCTCCCAAAGTGTTGGGATTACA
AACGTGAGAACCGTATTTTCAAATGTATTCAATAACACTACAGCGTTTCCAATTTTAAGA
GGAAGCAATTGCCACAAAATCACTGCCCCTGGTCTGGGCAAGGGGCAGTTGGTGAACTTG
CTGCCTCCAGAGAACCTTCCCTGGTGTGGAGGCAGCCAGGGACCCAGGATGCTCCGGACC
TGTTACGTGCTCTGTTCCCAAGCTGGTCCCCCCTCCAGGGGCTGGCAGTCCCTGAGCTTT
GATGGCGGGGCCTTCCACCTTAAGGGCACAGGAGAGCTGACACGGGCCTTGCTGGTTCTC
CGGCTGTGTGCCTGGCCCCCACTCGTCACTCACGGGCTGTTGCTCCAGGCCTGGTCTCGG
CGACTCCTGGGCTCCCGGCTCTCAGGCGCATTTCTCCGAGCATCCGTCTATGGGCAGTTT
GTGGCTGGTGAGACAGCAGAGGAGGTGAAGGGCTGCGTGCAGCAGCTGCGGACCCTCAGC
CTCCGACCACTGCTGGCAGTGCCCACTGAGGAGGAGCCGGACTCTGCTGCCAAGAGTGGT
GAGGCGTGGTATGAGGGGAACCTCGGTGCTATGCTGCGGTGTGTGGACCTGTCACGGGGC
CTCCTGGAGCCCCCCAGCCTGGCTGAGGCCAGCCTCATGCAGCTGAAGGTGACGGCGCTG
ACCAGTACTCGGCTCTGTAAGGAGCTAGCCTCGTGGGTCAGAAGGCCAGGAGCCTCCTTG
GAGCTGAGCCCCGAGAGGCTGGCTGAAGCTATGGACTCTGGGCAGAACCTCCAGGTCTCC
TGCCTCAATGCTGAGCAGAACCAGCACCTCCGGGCCTCCCTCAGCCGCCTGCATCGGGTG
GCACAGTATGCCCGGGCCCAGCACGTGCGGCTCCTGGTGGATGCGGAGTACACCTCACTG
AACCCTGCGCTCTCGCTGCTGGTGGCTGCCCTGGCTGTGCGCTGGAACAGCCCGGGTGAA
GGCGGGCCCTGGGTGTGGAACACCTACCAGGCCTGTCTAAAGGACACATTCGAGCGGCTG
GGGAGGGATGCAGAGGCTGCGCACAGGGCCGGCCTGGCCTTCGGAGTGAAGCTGGTACGA
GGTGCATATCTGGACAAGGAGAGAGCGGTGGCCCAGCTCCATGGGATGGAAGACCCCACT
CAGCCTGACTATGAGGCCACCAGTCAGAGTTACAGCCGCTGCCTGGAACTGATGCTGACG
CACGTGGCCCGCCATGGCCCCATGTGCCACCTCATGGTGGCTTCCCACAATGAGGAATCT
GTTCGCCAGGCAACCAAGCGCATGTGGGAGCTGGGCATTCCTCTGGATGGGACTGTCTGT
TTCGGACAACTTCTGGGCATGTGTGACCACGTCTCTCTAGCACTGGGGCAGGCCGGCTAT
GTAGTGTATAAGTCCATTCCCTATGGCTCCTTGGAGGAGGTAATCCCCTACCTGATCCGG
AGGGCCCAGGAGAACCGGAGCGTGCTTCAGGGTGCCCGCAGGGAACAGGAGCTGCTCAGC
CAAGAACTGTGGCGGCGGCTGCTGCCAGGATGCCGAAGGATACCCCACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 536 |
| Molecular Weight
| 58870.115 |
| Theoretical pI
| 8.598 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable proline dehydrogenase 2
MSPRVVSNSSVLASQSVGITNVRTVFSNVFNNTTAFPILRGSNCHKITAPGLGKGQLVNL
LPPENLPWCGGSQGPRMLRTCYVLCSQAGPPSRGWQSLSFDGGAFHLKGTGELTRALLVL
RLCAWPPLVTHGLLLQAWSRRLLGSRLSGAFLRASVYGQFVAGETAEEVKGCVQQLRTLS
LRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTAL
TSTRLCKELASWVRRPGASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRV
AQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERL
GRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLT
HVARHGPMCHLMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGY
VVYKSIPYGSLEEVIPYLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH
|
| External Links |
|---|
| GenBank ID Protein
| 6649583 |
| UniProtKB/Swiss-Prot ID
| Q9UF12 |
| UniProtKB/Swiss-Prot Entry Name
| PROD2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U80018 |
| GeneCard ID
| PRODH2 |
| GenAtlas ID
| PRODH2 |
| HGNC ID
| HGNC:17325 |
| References |
|---|
| General References
| Not Available |
