Hmdb loader
Identification
HMDB Protein ID HMDBP01386
Secondary Accession Numbers
  • 6682
Name Mitogen-activated protein kinase kinase kinase 12
Synonyms
  1. DLK
  2. Dual leucine zipper bearing kinase
  3. Leucine-zipper protein kinase
  4. MAPK-upstream kinase
  5. MUK
  6. Mixed lineage kinase
  7. ZPK
Gene Name MAP3K12
Protein Type Unknown
Biological Properties
General Function Involved in magnesium ion binding
Specific Function May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
magnesium ion binding
protein binding
protein kinase activity
protein serine/threonine kinase activity
identical protein binding
protein homodimerization activity
receptor signaling protein serine/threonine kinase activity
map kinase kinase kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
protein amino acid autophosphorylation
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 12q13
SNPs MAP3K12
Gene Sequence
>2580 bp
ATGGCTTGCCTCCATGAGACCCGAACACCCTCTCCTTCCTTTGGGGGCTTTGTGTCTACC
CTAAGTGAGGCATCCATGCGCAAGCTGGACCCAGACACTTCTGACTGCACTCCCGAGAAG
GACCTGACGCCTACCCATGTCCTGCAGCTACATGAGCAGGATGCAGGGGGCCCAGGGGGA
GCAGCTGGGTCACCTGAGAGTCGGGCATCCAGAGTTCGAGCTGACGAGGTGCGACTGCAG
TGCCAGAGTGGCAGTGGCTTCCTTGAGGGCCTCTTTGGCTGCCTGCGCCCTGTCTGGACC
ATGATTGGCAAAGCCTACTCCACTGAGCACAAGCAGCAGCAGGAAGACCTTTGGGAGGTC
CCCTTTGAGGAAATCCTGGACCTGCAGTGGGTGGGCTCAGGGGCCCAGGGTGCTGTCTTC
CTGGGGCGCTTCCACGGGGAGGAGGTGGCTGTGAAGAAGGTGCGAGACCTCAAAGAAACC
GACATCAAGCACTTGCGAAAGCTGAAGCACCCCAACATCATCACTTTCAAGGGTGTGTGC
ACCCAGGCTCCCTGCTACTGCATCCTCATGGAGTTCTGCGCCCAGGGCCAGCTGTATGAG
GTACTGCGGGCTGGCCGCCCTGTCACCCCCTCCTTACTGGTTGACTGGTCCATGGGCATC
GCTGGTGGCATGAACTACCTGCACCTGCACAAGATTATCCACAGGGATCTCAAGTCACCC
AACATGCTAATCACCTACGACGATGTGGTGAAGATCTCAGATTTTGGCACTTCCAAGGAG
CTGAGTGACAAGAGCACCAAGATGTCCTTTGCAGGGACAGTAGCCTGGATGGCCCCTGAG
GTGATCCGCAATGAACCTGTGTCTGAGAAGGTCGACATCTGGTCCTTTGGCGTGGTGCTA
TGGGAACTGCTGACTGGTGAGATCCCCTACAAAGACGTAGATTCCTCAGCCATTATCTGG
GGTGTGGGAAGCAACAGTCTCCATCTGCCCGTGCCCTCCAGTTGCCCAGATGGTTTCAAG
ATCCTGCTTCGCCAGTGCTGGAATAGCAAACCACGAAATCGCCCATCATTCCGACAGATC
CTGCTGCATCTGGACATTGCCTCAGCTGATGTACTCTCCACACCCCAGGAGACTTACTTT
AAGTCCCAGGCAGAGTGGCGGGAAGAAGTAAAACTGCACTTTGAAAAGATTAAGTCAGAA
GGGACCTGTCTGCACCGCCTAGAAGAGGAACTGGTGATGAGGAGGAGGGAGGAGCTCAGA
CACGCCCTGGACATCAGGGAGCACTATGAAAGGAAGCTGGAGAGAGCCAACAACCTGTAT
ATGGAACTTAATGCCCTCATGTTGCAGCTGGAACTCAAGGAGAGGGAGCTGCTCAGGCGA
GAGCAAGCTTTAGAGCGGAGGTGCCCAGGCCTGCTGAAGCCACACCCTTCCCGGGGCCTC
CTGCATGGAAACACAATGGAGAAGCTTATCAAGAAGAGGAATGTGCCACAGAAGCTGTCA
CCCCATAGCAAAAGGCCAGATATCCTCAAGACGGAGTCTTTGCTCCCTAAACTAGATGCA
GCCCTGAGTGGGGTGGGGCTTCCTGGGTGTCCTAAGGGCCCCCCCTCACCAGGACGGAGT
CGCCGTGGCAAGACCCGTCACCGCAAGGCCAGCGCCAAGGGGAGCTGTGGGGACCTGCCT
GGGCTTCGTACAGCTGTGCCACCCCATGAACCTGGAGGACCAGGAAGCCCAGGGGGCCTA
GGAGGGGGACCCTCAGCCTGGGAGGCCTGCCCTCCCGCCCTCCGTGGGCTTCATCATGAC
CTCCTGCTCCGCAAAATGTCTTCATCGTCCCCAGACCTGCTGTCAGCAGCACTAGGGTCC
CGGGGCCGGGGGGCCACAGGCGGAGCTGGGGATCCTGGCTCACCACCTCCGGCCCGGGGT
GACACCCCACCAAGTGAGGGCTCAGCCCCTGGCTCCACCAGCCCAGATTCACCTGGGGGA
GCCAAAGGGGAACCACCTCCTCCAGTAGGGCCTGGTGAAGGTGTGGGGCTTCTGGGAACT
GGAAGGGAAGGGACCTCAGGCCGGGGAGGAAGCCGGGCTGGGTCCCAGCACTTGACCCCA
GCTGCACTGCTGTACAGGGCTGCCGTCACCCGAAGTCAGAAACGTGGCATCTCATCGGAA
GAGGAGGAAGGAGAGGTAGACAGTGAAGTAGAGCTGACATCAAGCCAGAGGTGGCCTCAG
AGCCTGAACATGCGCCAGTCACTATCTACCTTCAGCTCAGAGAATCCATCAGATGGGGAG
GAAGGCACAGCTAGTGAACCTTCCCCCAGTGGCACACCTGAAGTTGGCAGCACCAACACT
GATGAGCGGCCAGATGAGCGGTCTGATGACATGTGCTCCCAGGGCTCAGAAATCCCACTG
GACCCACCTCCTTCAGAGGTCATCCCTGGCCCTGAACCCAGCTCCCTGCCCATTCCACAC
CAGGAACTTCTCAGAGAGCGGGGCCCTCCCAATTCTGAGGACTCAGACTGTGACAGCACT
GAATTGGACAACTCCAACAGCGTTGATGCCTTGCGGCCCCCAGCTTCCCTCCCTCCATGA
Protein Properties
Number of Residues 859
Molecular Weight 93218.2
Theoretical pI 6.42
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Mitogen-activated protein kinase kinase kinase 12
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
GenBank ID Protein 18265389
UniProtKB/Swiss-Prot ID Q12852
UniProtKB/Swiss-Prot Entry Name M3K12_HUMAN
PDB IDs Not Available
GenBank Gene ID AF283475
GeneCard ID MAP3K12
GenAtlas ID MAP3K12
HGNC ID HGNC:6851
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  4. Reddy UR, Pleasure D: Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. Biochem Biophys Res Commun. 1994 Jul 15;202(1):613-20. [PubMed:8037767 ]
  5. Itoh A, Wang Z, Ito Y, Reddy UR, Itoh T: SP3 acts as a positive regulator on the core promoter of human ZPK gene. Biochem Biophys Res Commun. 2004 Jan 16;313(3):612-8. [PubMed:14697235 ]
  6. Fukuyama K, Yoshida M, Yamashita A, Deyama T, Baba M, Suzuki A, Mohri H, Ikezawa Z, Nakajima H, Hirai S, Ohno S: MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase. J Biol Chem. 2000 Jul 14;275(28):21247-54. [PubMed:10801814 ]