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Showing metabocard for Benzoyl chloride (HMDB0249038)

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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2021-09-11 03:31:22 UTC
Update Date2021-09-26 22:59:38 UTC
HMDB IDHMDB0249038
Secondary Accession NumbersNone
Metabolite Identification
Common NameBenzoyl chloride
DescriptionBenzoyl chloride belongs to the class of organic compounds known as benzoic acids and derivatives. These are organic compounds containing a carboxylic acid substituent attached to a benzene ring. Based on a literature review a significant number of articles have been published on Benzoyl chloride. This compound has been identified in human blood as reported by (PMID: 31557052 ). Benzoyl chloride is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically Benzoyl chloride is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0249038 (Benzoyl chloride)


  Mrv1572004191601112D          

  9  9  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  2  0  0  0  0
  6  4  2  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  7  2  0  0  0  0
M  END
Download

3D MOL for HMDB0249038 (Benzoyl chloride)

HMDB0249038
     RDKit          3D
Benzoyl chloride
 14 14  0  0  0  0  0  0  0  0999 V2000
    2.8376   -1.2983   -0.0382 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2893   -0.1863   -0.1987 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3051    1.1819   -0.5697 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.8476   -0.0890   -0.0696 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1922    1.1274   -0.2394 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1749    1.2437   -0.1218 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9169    0.1206    0.1732 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2935   -1.0943    0.3460 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -1.1876    0.2231 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8187    1.9688   -0.4677 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6533    2.2084   -0.2607 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9928    0.1628    0.2754 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8751   -1.9987    0.5820 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5350   -2.1594    0.3659 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  5 10  1  0
  6 11  1  0
  7 12  1  0
  8 13  1  0
  9 14  1  0
M  END
Download

3D SDF for HMDB0249038 (Benzoyl chloride)


  Mrv1572004191601112D          

  9  9  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  2  0  0  0  0
  6  4  2  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  7  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0249038

> <DATABASE_NAME>
hmdb

> <SMILES>
ClC(=O)C1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C7H5ClO/c8-7(9)6-4-2-1-3-5-6/h1-5H

> <INCHI_KEY>
PASDCCFISLVPSO-UHFFFAOYSA-N

> <FORMULA>
C7H5ClO

> <MOLECULAR_WEIGHT>
140.57

> <EXACT_MASS>
140.0028925

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
14

> <JCHEM_AVERAGE_POLARIZABILITY>
13.128730155982478

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
benzoyl chloride

> <ALOGPS_LOGP>
1.82

> <JCHEM_LOGP>
2.164158369

> <ALOGPS_LOGS>
-2.42

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-8.969869371569686

> <JCHEM_POLAR_SURFACE_AREA>
17.07

> <JCHEM_REFRACTIVITY>
37.172700000000006

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.39e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
benzoyl chloride

> <JCHEM_VEBER_RULE>
1

$$$$
Download

3D-SDF for HMDB0249038 (Benzoyl chloride)

HMDB0249038
     RDKit          3D
Benzoyl chloride
 14 14  0  0  0  0  0  0  0  0999 V2000
    2.8376   -1.2983   -0.0382 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2893   -0.1863   -0.1987 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3051    1.1819   -0.5697 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.8476   -0.0890   -0.0696 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1922    1.1274   -0.2394 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1749    1.2437   -0.1218 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9169    0.1206    0.1732 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2935   -1.0943    0.3460 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -1.1876    0.2231 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8187    1.9688   -0.4677 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6533    2.2084   -0.2607 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9928    0.1628    0.2754 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8751   -1.9987    0.5820 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5350   -2.1594    0.3659 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  5 10  1  0
  6 11  1  0
  7 12  1  0
  8 13  1  0
  9 14  1  0
M  END
Download

PDB for HMDB0249038 (Benzoyl chloride)

HEADER    PROTEIN                                 19-APR-16   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   19-APR-16         0                                  
HETATM    1  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.000   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM    8 Cl   UNK     0       0.000   4.620   0.000  0.00  0.00          Cl+0
HETATM    9  O   UNK     0       2.667   4.620   0.000  0.00  0.00           O+0
CONECT    1    2    3                                                       
CONECT    2    1    4                                                       
CONECT    3    1    5                                                       
CONECT    4    2    6                                                       
CONECT    5    3    6                                                       
CONECT    6    4    5    7                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7                                                            
MASTER        0    0    0    0    0    0    0    0    9    0   18    0
END
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3D PDB for HMDB0249038 (Benzoyl chloride)

COMPND    HMDB0249038
HETATM    1  O1  UNL     1       2.838  -1.298  -0.038  1.00  0.00           O  
HETATM    2  C1  UNL     1       2.289  -0.186  -0.199  1.00  0.00           C  
HETATM    3 CL1  UNL     1       3.305   1.182  -0.570  1.00  0.00          CL  
HETATM    4  C2  UNL     1       0.848  -0.089  -0.070  1.00  0.00           C  
HETATM    5  C3  UNL     1       0.192   1.127  -0.239  1.00  0.00           C  
HETATM    6  C4  UNL     1      -1.175   1.244  -0.122  1.00  0.00           C  
HETATM    7  C5  UNL     1      -1.917   0.121   0.173  1.00  0.00           C  
HETATM    8  C6  UNL     1      -1.293  -1.094   0.346  1.00  0.00           C  
HETATM    9  C7  UNL     1       0.081  -1.188   0.223  1.00  0.00           C  
HETATM   10  H1  UNL     1       0.819   1.969  -0.468  1.00  0.00           H  
HETATM   11  H2  UNL     1      -1.653   2.208  -0.261  1.00  0.00           H  
HETATM   12  H3  UNL     1      -2.993   0.163   0.275  1.00  0.00           H  
HETATM   13  H4  UNL     1      -1.875  -1.999   0.582  1.00  0.00           H  
HETATM   14  H5  UNL     1       0.535  -2.159   0.366  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    4    5    5    9
CONECT    5    6   10
CONECT    6    7    7   11
CONECT    7    8   12
CONECT    8    9    9   13
CONECT    9   14
END
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SMILES for HMDB0249038 (Benzoyl chloride)

ClC(=O)C1=CC=CC=C1
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INCHI for HMDB0249038 (Benzoyl chloride)

InChI=1S/C7H5ClO/c8-7(9)6-4-2-1-3-5-6/h1-5H
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View in JSmolView Stereo Labels
Synonyms
ValueSource
alpha-ChlorobenzaldehydeChEBI
Benzenecarbonyl chlorideChEBI
Benzoic acid chlorideChEBI
a-ChlorobenzaldehydeGenerator
Α-chlorobenzaldehydeGenerator
Benzoate chlorideGenerator
Chemical FormulaC7H5ClO
Average Molecular Weight140.57
Monoisotopic Molecular Weight140.0028925
IUPAC Namebenzoyl chloride
Traditional Namebenzoyl chloride
CAS Registry NumberNot Available
SMILES
ClC(=O)C1=CC=CC=C1
InChI Identifier
InChI=1S/C7H5ClO/c8-7(9)6-4-2-1-3-5-6/h1-5H
InChI KeyPASDCCFISLVPSO-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzoic acids and derivatives. These are organic compounds containing a carboxylic acid substituent attached to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentBenzoic acids and derivatives
Alternative Parents
Substituents
  • Benzoic acid or derivatives
  • Benzoyl
  • Acyl halide
  • Acyl chloride
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
ProcessNot Available
RoleNot Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP1.82ALOGPS
logP2.16ChemAxon
logS-2.4ALOGPS
pKa (Strongest Basic)-9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.07 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity37.17 m³·mol⁻¹ChemAxon
Polarizability13.13 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+125.08530932474
DeepCCS[M-H]-121.53230932474
DeepCCS[M-2H]-158.68530932474
DeepCCS[M+Na]+133.89630932474
AllCCS[M+H]+127.032859911
AllCCS[M+H-H2O]+122.232859911
AllCCS[M+NH4]+131.432859911
AllCCS[M+Na]+132.732859911
AllCCS[M-H]-122.132859911
AllCCS[M+Na-2H]-124.132859911
AllCCS[M+HCOO]-126.332859911

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Predicted by Siyang on May 30, 202213.2628 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20222.84 minutes32390414
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid1793.2 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid536.2 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid203.4 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid356.3 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid286.5 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid516.1 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid625.3 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)203.3 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid1115.7 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid431.0 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid1164.7 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid394.7 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid415.6 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate550.8 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA406.4 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water129.0 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Benzoyl chlorideClC(=O)C1=CC=CC=C11651.6Standard polar33892256
Benzoyl chlorideClC(=O)C1=CC=CC=C11044.3Standard non polar33892256
Benzoyl chlorideClC(=O)C1=CC=CC=C11113.0Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Benzoyl chloride GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4l-4900000000-03558d710c07430b038b2021-09-23Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Benzoyl chloride GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 10V, Positive-QTOFsplash10-0006-0900000000-44830e69555ae84ca3902016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 20V, Positive-QTOFsplash10-0006-0900000000-b2633f85a4c2dbaa12162016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 40V, Positive-QTOFsplash10-0a4i-3900000000-9c9434d9224a7f05dfd32016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 10V, Negative-QTOFsplash10-000i-0900000000-a9b3791d44885d9ad2cf2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 20V, Negative-QTOFsplash10-000i-0900000000-cdad4160a5672a0bc7572016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 40V, Negative-QTOFsplash10-0udi-0900000000-9f66e7ccfbcf7ef1a2fa2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 10V, Positive-QTOFsplash10-0006-0900000000-b48c4f90c54a0083bedc2021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 20V, Positive-QTOFsplash10-0a4l-0900000000-dff5f1ce470b650f1c182021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 40V, Positive-QTOFsplash10-0udi-9200000000-2cb2431010779306c7d62021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 10V, Negative-QTOFsplash10-000i-0900000000-bb57b9ccee4a614433772021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 20V, Negative-QTOFsplash10-001i-9200000000-5008368e887753e33f542021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzoyl chloride 40V, Negative-QTOFsplash10-001i-9200000000-64e426833c4129b2659e2021-10-12Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDC00038199
Chemspider ID7134
KEGG Compound IDC19168
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkBenzoyl_chloride
METLIN IDNot Available
PubChem Compound7412
PDB IDNot Available
ChEBI ID82275
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1222201
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Barupal DK, Fiehn O: Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Environ Health Perspect. 2019 Sep;127(9):97008. doi: 10.1289/EHP4713. Epub 2019 Sep 26. [PubMed:31557052 ]