Hmdb loader

Showing metabocard for MG(0:0/15:0/0:0) (HMDB0011532)

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enzymes (8) Show 8 proteins
Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2009-01-08 17:24:04 UTC
Update Date2022-11-30 19:04:00 UTC
HMDB IDHMDB0011532
Secondary Accession Numbers
  • HMDB11532
Metabolite Identification
Common NameMG(0:0/15:0/0:0)
DescriptionMG(0:0/15:0/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups; 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1-/3-isomers are not distinguished from each other and are termed 'alpha-monoacylglycerols', while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and Diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well.
Structure
Data?1582752918
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0011532 (MG(0:0/15:0/0:0))


  Mrv0541 02241201442D          

 23 22  0  0  1  0            999 V2000
   22.4212   -6.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.7459   -7.3252    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   21.0705   -6.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.0966   -7.3252    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.3952   -7.3252    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   21.2889   -7.8953    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   22.2639   -7.9250    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.5791   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2940   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0089   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7234   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4382   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1528   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8677   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5822   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2857   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0003   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7151   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.4297   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1446   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.8591   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5740   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5740   -9.1262    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  1  1  0  0  0  0
  5  3  1  0  0  0  0
  2  6  1  6  0  0  0
  2  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22  6  1  0  0  0  0
M  END
Download

3D MOL for HMDB0011532 (MG(0:0/15:0/0:0))

HMDB0011532
     RDKit          3D
MG(0:0/15:0/0:0)
 58 57  0  0  0  0  0  0  0  0999 V2000
    5.4158   -0.8260    1.7328 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3211   -0.2253    0.6838 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2748    1.2538    0.6057 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9939    1.9020    0.3048 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3122    1.6662   -0.9688 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7843    0.3243   -1.2976 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7154   -0.1641   -0.3375 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2930   -1.5429   -0.7735 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2386   -2.1281    0.1023 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0437   -1.2976    0.1511 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6444   -1.1715   -1.2176 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9269   -0.3856   -1.2129 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6875    0.9898   -0.7161 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9052    1.8673   -0.6876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9866    1.3537    0.1704 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8656    1.5662    1.4113 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1040    0.6723   -0.2425 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1123    0.2001    0.6183 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1535   -1.3088    0.4538 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1375   -1.8082    1.2903 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4763    0.7309    0.3173 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3551    0.1773    1.2481 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9259   -1.3449    2.5439 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8070   -0.0237    2.1944 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7043   -1.5444    1.2519 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3502   -0.7673   -0.2581 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3903   -0.4449    1.1119 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.0969    1.6041   -0.0963 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6545    1.6717    1.5988 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3136    1.6937    1.2009 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1588    3.0352    0.3748 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4866    2.4205   -1.1512 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0481    1.9253   -1.7944 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5771   -0.3947   -1.4885 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2627    0.4190   -2.3092 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8039    0.4962   -0.5302 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9279   -0.0339    0.7113 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9509   -1.4927   -1.8132 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1670   -2.2479   -0.7320 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5721   -2.2415    1.1438 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9674   -3.1276   -0.3188 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7388   -1.8528    0.8019 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2344   -0.3104    0.5891 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0941   -0.7343   -1.9338 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8026   -2.2191   -1.5959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6313   -0.9714   -0.5487 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3029   -0.4130   -2.2711 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2520    0.9453    0.2972 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9433    1.4777   -1.3759 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3170    2.0385   -1.7041 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6000    2.8586   -0.2916 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8465    0.4735    1.6533 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1420   -1.6751    0.7428 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3848   -1.5662   -0.5957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9364   -1.5500    2.2319 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5489    1.8357    0.4472 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8489    0.4399   -0.6870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1487   -0.2248    0.8150 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 18 21  1  0
 21 22  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  2 26  1  0
  2 27  1  0
  3 28  1  0
  3 29  1  0
  4 30  1  0
  4 31  1  0
  5 32  1  0
  5 33  1  0
  6 34  1  0
  6 35  1  0
  7 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  0
  9 41  1  0
 10 42  1  0
 10 43  1  0
 11 44  1  0
 11 45  1  0
 12 46  1  0
 12 47  1  0
 13 48  1  0
 13 49  1  0
 14 50  1  0
 14 51  1  0
 18 52  1  0
 19 53  1  0
 19 54  1  0
 20 55  1  0
 21 56  1  0
 21 57  1  0
 22 58  1  0
M  END
Download

3D SDF for HMDB0011532 (MG(0:0/15:0/0:0))


  Mrv0541 02241201442D          

 23 22  0  0  1  0            999 V2000
   22.4212   -6.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.7459   -7.3252    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   21.0705   -6.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.0966   -7.3252    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.3952   -7.3252    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   21.2889   -7.8953    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   22.2639   -7.9250    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.5791   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2940   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0089   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7234   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4382   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1528   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8677   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5822   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2857   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0003   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7151   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.4297   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1446   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.8591   -7.8953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5740   -8.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5740   -9.1262    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  1  1  0  0  0  0
  5  3  1  0  0  0  0
  2  6  1  6  0  0  0
  2  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22  6  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0011532

> <DATABASE_NAME>
hmdb

> <SMILES>
[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCC

> <INCHI_IDENTIFIER>
InChI=1S/C18H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18(21)22-17(15-19)16-20/h17,19-20H,2-16H2,1H3

> <INCHI_KEY>
SJUYTIGRIZBTCI-UHFFFAOYSA-N

> <FORMULA>
C18H36O4

> <MOLECULAR_WEIGHT>
316.476

> <EXACT_MASS>
316.26135964

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
40.10899570156569

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
1,3-dihydroxypropan-2-yl pentadecanoate

> <ALOGPS_LOGP>
5.30

> <JCHEM_LOGP>
4.637471214666666

> <ALOGPS_LOGS>
-4.37

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.979619369539545

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.278372843553583

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9827691981262365

> <JCHEM_POLAR_SURFACE_AREA>
66.75999999999999

> <JCHEM_REFRACTIVITY>
89.50649999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
17

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.34e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
1,3-dihydroxypropan-2-yl pentadecanoate

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0011532 (MG(0:0/15:0/0:0))

HMDB0011532
     RDKit          3D
MG(0:0/15:0/0:0)
 58 57  0  0  0  0  0  0  0  0999 V2000
    5.4158   -0.8260    1.7328 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3211   -0.2253    0.6838 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2748    1.2538    0.6057 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9939    1.9020    0.3048 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3122    1.6662   -0.9688 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7843    0.3243   -1.2976 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7154   -0.1641   -0.3375 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2930   -1.5429   -0.7735 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2386   -2.1281    0.1023 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0437   -1.2976    0.1511 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6444   -1.1715   -1.2176 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9269   -0.3856   -1.2129 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6875    0.9898   -0.7161 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9052    1.8673   -0.6876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9866    1.3537    0.1704 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8656    1.5662    1.4113 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1040    0.6723   -0.2425 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1123    0.2001    0.6183 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1535   -1.3088    0.4538 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1375   -1.8082    1.2903 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4763    0.7309    0.3173 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3551    0.1773    1.2481 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9259   -1.3449    2.5439 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8070   -0.0237    2.1944 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7043   -1.5444    1.2519 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3502   -0.7673   -0.2581 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3903   -0.4449    1.1119 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.0969    1.6041   -0.0963 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6545    1.6717    1.5988 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3136    1.6937    1.2009 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1588    3.0352    0.3748 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4866    2.4205   -1.1512 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0481    1.9253   -1.7944 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5771   -0.3947   -1.4885 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2627    0.4190   -2.3092 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8039    0.4962   -0.5302 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9279   -0.0339    0.7113 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9509   -1.4927   -1.8132 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1670   -2.2479   -0.7320 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5721   -2.2415    1.1438 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9674   -3.1276   -0.3188 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7388   -1.8528    0.8019 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2344   -0.3104    0.5891 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0941   -0.7343   -1.9338 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8026   -2.2191   -1.5959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6313   -0.9714   -0.5487 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3029   -0.4130   -2.2711 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2520    0.9453    0.2972 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9433    1.4777   -1.3759 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3170    2.0385   -1.7041 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6000    2.8586   -0.2916 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8465    0.4735    1.6533 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1420   -1.6751    0.7428 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3848   -1.5662   -0.5957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9364   -1.5500    2.2319 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5489    1.8357    0.4472 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8489    0.4399   -0.6870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1487   -0.2248    0.8150 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 18 21  1  0
 21 22  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  2 26  1  0
  2 27  1  0
  3 28  1  0
  3 29  1  0
  4 30  1  0
  4 31  1  0
  5 32  1  0
  5 33  1  0
  6 34  1  0
  6 35  1  0
  7 36  1  0
  7 37  1  0
  8 38  1  0
  8 39  1  0
  9 40  1  0
  9 41  1  0
 10 42  1  0
 10 43  1  0
 11 44  1  0
 11 45  1  0
 12 46  1  0
 12 47  1  0
 13 48  1  0
 13 49  1  0
 14 50  1  0
 14 51  1  0
 18 52  1  0
 19 53  1  0
 19 54  1  0
 20 55  1  0
 21 56  1  0
 21 57  1  0
 22 58  1  0
M  END
Download

PDB for HMDB0011532 (MG(0:0/15:0/0:0))

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0      41.853 -12.946   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      40.592 -13.674   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      39.332 -12.946   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      43.114 -13.674   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      38.071 -13.674   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0      39.739 -14.738   0.000  0.00  0.00           O+0
HETATM    7  H   UNK     0      41.559 -14.793   0.000  0.00  0.00           H+0
HETATM    8  C   UNK     0      19.748 -15.508   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      21.082 -14.738   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      22.417 -15.508   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      23.750 -14.738   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      25.085 -15.508   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      26.419 -14.738   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      27.753 -15.508   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      29.087 -14.738   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      30.400 -15.508   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      31.734 -14.738   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      33.068 -15.508   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      34.402 -14.738   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      35.737 -15.508   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      37.070 -14.738   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      38.405 -15.508   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      38.405 -17.036   0.000  0.00  0.00           O+0
CONECT    1    2    4                                                       
CONECT    2    1    3    6    7                                             
CONECT    3    2    5                                                       
CONECT    4    1                                                            
CONECT    5    3                                                            
CONECT    6    2   22                                                       
CONECT    7    2                                                            
CONECT    8    9                                                            
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23    6                                                  
CONECT   23   22                                                            
MASTER        0    0    0    0    0    0    0    0   23    0   44    0
END
Download

3D PDB for HMDB0011532 (MG(0:0/15:0/0:0))

COMPND    HMDB0011532
HETATM    1  C1  UNL     1       5.416  -0.826   1.733  1.00  0.00           C  
HETATM    2  C2  UNL     1       6.321  -0.225   0.684  1.00  0.00           C  
HETATM    3  C3  UNL     1       6.275   1.254   0.606  1.00  0.00           C  
HETATM    4  C4  UNL     1       4.994   1.902   0.305  1.00  0.00           C  
HETATM    5  C5  UNL     1       4.312   1.666  -0.969  1.00  0.00           C  
HETATM    6  C6  UNL     1       3.784   0.324  -1.298  1.00  0.00           C  
HETATM    7  C7  UNL     1       2.715  -0.164  -0.338  1.00  0.00           C  
HETATM    8  C8  UNL     1       2.293  -1.543  -0.773  1.00  0.00           C  
HETATM    9  C9  UNL     1       1.239  -2.128   0.102  1.00  0.00           C  
HETATM   10  C10 UNL     1      -0.044  -1.298   0.151  1.00  0.00           C  
HETATM   11  C11 UNL     1      -0.644  -1.171  -1.218  1.00  0.00           C  
HETATM   12  C12 UNL     1      -1.927  -0.386  -1.213  1.00  0.00           C  
HETATM   13  C13 UNL     1      -1.687   0.990  -0.716  1.00  0.00           C  
HETATM   14  C14 UNL     1      -2.905   1.867  -0.688  1.00  0.00           C  
HETATM   15  C15 UNL     1      -3.987   1.354   0.170  1.00  0.00           C  
HETATM   16  O1  UNL     1      -3.866   1.566   1.411  1.00  0.00           O  
HETATM   17  O2  UNL     1      -5.104   0.672  -0.242  1.00  0.00           O  
HETATM   18  C16 UNL     1      -6.112   0.200   0.618  1.00  0.00           C  
HETATM   19  C17 UNL     1      -6.153  -1.309   0.454  1.00  0.00           C  
HETATM   20  O3  UNL     1      -7.138  -1.808   1.290  1.00  0.00           O  
HETATM   21  C18 UNL     1      -7.476   0.731   0.317  1.00  0.00           C  
HETATM   22  O4  UNL     1      -8.355   0.177   1.248  1.00  0.00           O  
HETATM   23  H1  UNL     1       5.926  -1.345   2.544  1.00  0.00           H  
HETATM   24  H2  UNL     1       4.807  -0.024   2.194  1.00  0.00           H  
HETATM   25  H3  UNL     1       4.704  -1.544   1.252  1.00  0.00           H  
HETATM   26  H4  UNL     1       6.350  -0.767  -0.258  1.00  0.00           H  
HETATM   27  H5  UNL     1       7.390  -0.445   1.112  1.00  0.00           H  
HETATM   28  H6  UNL     1       7.097   1.604  -0.096  1.00  0.00           H  
HETATM   29  H7  UNL     1       6.654   1.672   1.599  1.00  0.00           H  
HETATM   30  H8  UNL     1       4.314   1.694   1.201  1.00  0.00           H  
HETATM   31  H9  UNL     1       5.159   3.035   0.375  1.00  0.00           H  
HETATM   32  H10 UNL     1       3.487   2.420  -1.151  1.00  0.00           H  
HETATM   33  H11 UNL     1       5.048   1.925  -1.794  1.00  0.00           H  
HETATM   34  H12 UNL     1       4.577  -0.395  -1.488  1.00  0.00           H  
HETATM   35  H13 UNL     1       3.263   0.419  -2.309  1.00  0.00           H  
HETATM   36  H14 UNL     1       1.804   0.496  -0.530  1.00  0.00           H  
HETATM   37  H15 UNL     1       2.928  -0.034   0.711  1.00  0.00           H  
HETATM   38  H16 UNL     1       1.951  -1.493  -1.813  1.00  0.00           H  
HETATM   39  H17 UNL     1       3.167  -2.248  -0.732  1.00  0.00           H  
HETATM   40  H18 UNL     1       1.572  -2.242   1.144  1.00  0.00           H  
HETATM   41  H19 UNL     1       0.967  -3.128  -0.319  1.00  0.00           H  
HETATM   42  H20 UNL     1      -0.739  -1.853   0.802  1.00  0.00           H  
HETATM   43  H21 UNL     1       0.234  -0.310   0.589  1.00  0.00           H  
HETATM   44  H22 UNL     1       0.094  -0.734  -1.934  1.00  0.00           H  
HETATM   45  H23 UNL     1      -0.803  -2.219  -1.596  1.00  0.00           H  
HETATM   46  H24 UNL     1      -2.631  -0.971  -0.549  1.00  0.00           H  
HETATM   47  H25 UNL     1      -2.303  -0.413  -2.271  1.00  0.00           H  
HETATM   48  H26 UNL     1      -1.252   0.945   0.297  1.00  0.00           H  
HETATM   49  H27 UNL     1      -0.943   1.478  -1.376  1.00  0.00           H  
HETATM   50  H28 UNL     1      -3.317   2.039  -1.704  1.00  0.00           H  
HETATM   51  H29 UNL     1      -2.600   2.859  -0.292  1.00  0.00           H  
HETATM   52  H30 UNL     1      -5.846   0.474   1.653  1.00  0.00           H  
HETATM   53  H31 UNL     1      -5.142  -1.675   0.743  1.00  0.00           H  
HETATM   54  H32 UNL     1      -6.385  -1.566  -0.596  1.00  0.00           H  
HETATM   55  H33 UNL     1      -6.936  -1.550   2.232  1.00  0.00           H  
HETATM   56  H34 UNL     1      -7.549   1.836   0.447  1.00  0.00           H  
HETATM   57  H35 UNL     1      -7.849   0.440  -0.687  1.00  0.00           H  
HETATM   58  H36 UNL     1      -9.149  -0.225   0.815  1.00  0.00           H  
CONECT    1    2   23   24   25
CONECT    2    3   26   27
CONECT    3    4   28   29
CONECT    4    5   30   31
CONECT    5    6   32   33
CONECT    6    7   34   35
CONECT    7    8   36   37
CONECT    8    9   38   39
CONECT    9   10   40   41
CONECT   10   11   42   43
CONECT   11   12   44   45
CONECT   12   13   46   47
CONECT   13   14   48   49
CONECT   14   15   50   51
CONECT   15   16   16   17
CONECT   17   18
CONECT   18   19   21   52
CONECT   19   20   53   54
CONECT   20   55
CONECT   21   22   56   57
CONECT   22   58
END
Download

SMILES for HMDB0011532 (MG(0:0/15:0/0:0))

[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCC
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INCHI for HMDB0011532 (MG(0:0/15:0/0:0))

InChI=1S/C18H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18(21)22-17(15-19)16-20/h17,19-20H,2-16H2,1H3
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View in JSmolView Stereo Labels
Synonyms
ValueSource
1-MonoacylglycerideHMDB
1-MonoacylglycerolHMDB
2-Pentadecanoyl-glycerolHMDB
2-Pentadecanoyl-rac-glycerolHMDB
b-MonoacylglycerolHMDB
beta-MonoacylglycerolHMDB
MAG(0:0/15:0)HMDB
MAG(15:0)HMDB
MG(0:0/15:0)HMDB
MG(15:0)HMDB
1,3-Dihydroxypropan-2-yl pentadecanoic acidHMDB
Chemical FormulaC18H36O4
Average Molecular Weight316.476
Monoisotopic Molecular Weight316.26135964
IUPAC Name1,3-dihydroxypropan-2-yl pentadecanoate
Traditional Name1,3-dihydroxypropan-2-yl pentadecanoate
CAS Registry NumberNot Available
SMILES
[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCC
InChI Identifier
InChI=1S/C18H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18(21)22-17(15-19)16-20/h17,19-20H,2-16H2,1H3
InChI KeySJUYTIGRIZBTCI-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 2-monoacylglycerols. These are monoacylglycerols containing a glycerol acylated at the 2-position.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerolipids
Sub ClassMonoradylglycerols
Direct Parent2-monoacylglycerols
Alternative Parents
Substituents
  • 2-acyl-sn-glycerol
  • Fatty acid ester
  • Fatty acyl
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
Not AvailableNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.013 g/LALOGPS
logP5.3ALOGPS
logP4.64ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)14.28ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.76 ŲChemAxon
Rotatable Bond Count17ChemAxon
Refractivity89.51 m³·mol⁻¹ChemAxon
Polarizability40.11 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+183.79731661259
DarkChem[M-H]-182.79931661259
DeepCCS[M+H]+184.24630932474
DeepCCS[M-H]-181.88830932474
DeepCCS[M-2H]-215.00330932474
DeepCCS[M+Na]+190.33930932474
AllCCS[M+H]+186.132859911
AllCCS[M+H-H2O]+183.532859911
AllCCS[M+NH4]+188.632859911
AllCCS[M+Na]+189.332859911
AllCCS[M-H]-184.632859911
AllCCS[M+Na-2H]-185.832859911
AllCCS[M+HCOO]-187.332859911

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.10.0 minutes32390414
Predicted by Siyang on May 30, 202218.2307 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20221.35 minutes32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid37.3 seconds40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid3097.5 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid375.6 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid204.3 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid192.7 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid559.2 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid784.7 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid775.4 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)119.8 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid1695.1 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid584.1 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid1789.9 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid606.3 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid461.9 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate527.2 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA383.5 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water14.7 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MG(0:0/15:0/0:0)[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCC3268.9Standard polar33892256
MG(0:0/15:0/0:0)[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCC2297.7Standard non polar33892256
MG(0:0/15:0/0:0)[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCC2404.7Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
MG(0:0/15:0/0:0),1TMS,isomer #1CCCCCCCCCCCCCCC(=O)OC(CO)CO[Si](C)(C)C2435.9Semi standard non polar33892256
MG(0:0/15:0/0:0),2TMS,isomer #1CCCCCCCCCCCCCCC(=O)OC(CO[Si](C)(C)C)CO[Si](C)(C)C2486.5Semi standard non polar33892256
MG(0:0/15:0/0:0),1TBDMS,isomer #1CCCCCCCCCCCCCCC(=O)OC(CO)CO[Si](C)(C)C(C)(C)C2680.2Semi standard non polar33892256
MG(0:0/15:0/0:0),2TBDMS,isomer #1CCCCCCCCCCCCCCC(=O)OC(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C2965.5Semi standard non polar33892256
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Feces
Tissue Locations
  • All Tissues
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal		 details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer		 details
Associated Disorders and Diseases
Disease References
Colorectal cancer
  1. Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20. [PubMed:28587349 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB028248
KNApSAcK IDNot Available
Chemspider ID467962
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound537297
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  2. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  3. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  4. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  5. Ghosh S, Strum JC, Bell RM: Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling. FASEB J. 1997 Jan;11(1):45-50. [PubMed:9034165 ]
  6. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Enzymes

Enzyme Details
1. Monoglyceride lipase
General function:
Lipid transport and metabolism
Specific function:
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Gene Name:
MGLL
Uniprot ID:
Q99685
Molecular weight:
Not Available
Enzyme Details
2. Hormone-sensitive lipase
General function:
Involved in hydrolase activity
Specific function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Gene Name:
LIPE
Uniprot ID:
Q05469
Molecular weight:
116596.715
Enzyme Details
3. 2-acylglycerol O-acyltransferase 2
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.
Gene Name:
MOGAT2
Uniprot ID:
Q3SYC2
Molecular weight:
38195.285
Enzyme Details
4. 2-acylglycerol O-acyltransferase 1
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).
Gene Name:
MOGAT1
Uniprot ID:
Q96PD6
Molecular weight:
38812.19
Enzyme Details
5. 2-acylglycerol O-acyltransferase 3
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.
Gene Name:
MOGAT3
Uniprot ID:
Q86VF5
Molecular weight:
38729.84
Enzyme Details
6. Lysophosphatidic acid phosphatase type 6
General function:
Involved in acid phosphatase activity
Specific function:
Hydrolyzes lysophosphatidic acid to monoacylglycerol.
Gene Name:
ACP6
Uniprot ID:
Q9NPH0
Molecular weight:
48853.955
Enzyme Details
7. Acylglycerol kinase, mitochondrial
General function:
Involved in NAD+ kinase activity
Specific function:
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth
Gene Name:
AGK
Uniprot ID:
Q53H12
Molecular weight:
47136.8
Enzyme Details
8. Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
General function:
Involved in catalytic activity
Specific function:
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
Gene Name:
ENPP6
Uniprot ID:
Q6UWR7
Molecular weight:
50240.625